Effects of Serotonin Transporter Promoter Polymorphisms on Serotonin Function
نویسندگان
چکیده
منابع مشابه
Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism.
A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) is considered to be a plausible candidate gene for anxiety-related personality traits and for alcoholism. Empirical support for the association between 5-HTTLPR and psychological traits has been somewhat inconsistent; however, observations of the functional dominance of the low-activity s-allele over...
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CONTEXT Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) influence transcription and may play a role in the pathogenesis and course of depression. Recent research demonstrates that specific polymorphisms may be associated with differences in hippocampal volumes in subjects with depression. OBJECTIVE To examine associations between 5-HTTLPR genotype and hippoca...
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The pathogenesis of bipolar disorder may involve, at least in part, aberrations in serotonergic neurotransmission. Hence, serotonergic genes are attractive targets for association studies of bipolar disorder. We have reviewed the literature in this field. It is difficult to synthesize results as only one polymorphism per gene was typically investigated in relatively small samples. Nevertheless,...
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BACKGROUND Loss of parent during childhood or loss of partner has been associated with adulthood depression. The serotonin transporter polymorphism (5-HTTLPR) has been reported to moderate stress sensitivity reflected for example in the relationship between childhood maltreatment and depression. Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or ...
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August 2010 Volume 10, Issue 4 T he serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of cardiovascular diseases and disorders. Therefore, the regulation of the transporter’s activity represents a key mechanism to stabilize the concentration of plasma 5HT. There is a bipha...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2004
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300552